MIT Technology Review tales on our startup Genomic Prediction. Some major points worth clarifying:
1. GP's first product, announced at the annual ASRM (American Society of Reproductive Medicine) meeting this week, tests chromosomal abnormality. It is a a lot lower priced but more excellent fashion of reward tests.
2. The polygenic product, to be launched in 2018, tests for hundreds of known single-gene ("Mendelian") malady risks, and will possibly have a number of true polygenic predictive capabilities. This last part is in all probability some of the foremost very very very good emphasis of the story, but it is merely one thing of the customary product offering. The article elides a lot of tough laboratory work on DNA amplification, etc.
3. GP will merely deliver results requested by manner of capability of an IVF physician. It is not a DTC (Direct to Consumer) company.
4. All medical risk examine proceeds from statistical book (analyzing groups of people) to offer tips concerning a actual individual.
5. I am at the Board of Directors of GP but am now not an employee of the company.
MIT Technology Review
Eugenics 2.0: We’re at the Dawn of Choosing Embryos by manner of capability of Health, Height, and More
Will you be among the major to move along with your kids’ IQ? As machine discovering out unlocks predictions from DNA databases, scientists say people would possibly have alternatives by manner of capability of no capability before possible.
Nathan Treff was diagnosed with type 1 diabetes at 24. It’s a malady that runs in families, nonetheless it has complex causes. More than one gene is involved. And the environment plays a role too.
So you don’t recognize who will get it. Treff’s grandfather had it, and lost a leg. But Treff’s three young kids are fine, so far. He’s crossing his fingers they won’t develop it later.
Now Treff, an in vitro fertilization specialist, is working on a radical solution to switch the odds. Using a combination of pc computer sets and DNA tests, the startup brand he’s working with, Genomic Prediction, thinks it has a technique of predicting which IVF embryos in a laboratory dish could also be most possibly to develop type 1 diabetes or other complex diseases. Armed with such statistical scorecards, doctors and people would possibly huddle and judge to maintain clear of embryos with failing grades.
IVF clinics already test the DNA of embryos to spot rare diseases, like cystic fibrosis, consequently of defects in a single gene. But those “preimplantation” tests are poised for a dramatic soar forward as it becomes you will to peer more deeply at an embryo’s genome and create huge statistical forecasts concerning the person this could become.
The boost is occurring, say scientists, as a consequence of a growing flood of genetic book collected from large population studies. ...
The company’s plans rely on a tidal wave of recent knowledge displaying how small genetic differences can add as a lot as positioned one person, but now not another, at high odds for diabetes, a neurotic personality, or a taller or shorter height. Already, such “polygenic risk scores” are used in direct-to-consumer gene tests, akin to tales from 23andMe that tell customers their genetic likelihood of being overweight.
For adults, risk ratings are little more than a novelty or a offer of properly being advice they'll ignore. But if the similar information is generated about an embryo, it would possibly end end effect in existential consequences: who would possibly be born, and who stays in a laboratory freezer.
“I remind my partners, ‘You know, if my people had this test, I wouldn’t be here,’” says Treff, a prize-winning knowledgeable on diagnostic technology who is the writer of more than 90 medical papers.
Genomic Prediction was founded mostly this yr and has raised funds from undertaking capitalists in Silicon Valley, though it declines to declare who they are. Tellier, whose idea is the science fiction film Gattaca, says the brand plans to offer tales to IVF doctors and people identifying “outliers”-those embryos whose genetic ratings positioned them at the improper cease of a statistical curve for disorders akin to diabetes, late-life osteoporosis, schizophrenia, and dwarfism, depending on despite even when sets for those troubles reward accurate. ...
This week, Genomic Prediction manned a gross income area at the annual meeting of the American Society for Reproductive Medicine. That organization, which represents fertility doctors and scientists, has previously stated it thinks testing embryos for late-life conditions, like Alzheimer’s, could also be “ethically justified.” It cited, among other reasons, the “reproductive liberty” of parents.
... Hsu’s prediction is that “billionaires and Silicon Valley types” would possibly be the early adopters of embryo type technology, becoming among the major “to do IVF even though they don’t desire IVF.” As they start producing fewer unhealthy children, and more good ones, the rest of society would possibly follow suit.
“I fully predict it's going to be possible,” says Hsu of choosing embryos with higher IQ scores. “But we’ve stated that we as a brand typically are normally not going to do it. It’s a tough issue, like nuclear weapons or gene editing. There would possibly be a number of fate debate over despite even when this must be legal, or made illegal. Countries would possibly have referendums on it.”
Thank You and Good article MIT Technology Review this time, hopefully can benefit for you all. see you in other article postings.
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